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. 2021 May 18;35(6):e21651. doi: 10.1096/fj.202100560R

FIGURE 6.

FIGURE 6

Compounds inhibited pseudoviral and viral entry into cells. A‐D, Pseudoviruses encoding firefly luciferase and GFP were incubated with the indicated concentrations of compounds for 30 minutes and added to ACE2‐expressing HEK293 cells. After 24 hours, cells were lysed and a dual luciferase test was performed (A‐C) or GFP was measured (D). E, F, SARS‐CoV‐2‐GFP reporter virus signal upon 24 hours infection of A549‐ACE2 cells, pre‐treated for 3 hours with the indicated concentrations of (E) NACA and (F) auranofin. An experiment of two independent experiments is shown as mean ± SEM. Combined means from two (C), three (B, D), and four (A) independent experiments are shown as mean ± SEM P values of <.05 (*), <.01 (**), <.001 (***), or .0001 (****) are indicated; n.s.‐not significant