FIGURE 7.

Inhibition of pseudoviral contagion in mice by thiol‐reducing compounds. A, B, Mice were drinking 3% L‐ascorbic acid in tap water or tap water for six consecutive days. (C, D) NACA in PBS (3.0 mg/mouse) and auranofin in buffer (0.25 mg/mouse) or buffer were injected i.p. for two consecutive days. On day 2 (NACA and auranofin) or 6 (L‐ascorbic acid) mice were transfected with human ACE2 and TMPRSS2, and after 24 hours, pseudovirus‐carrying firefly luciferase were intranasally applied. After 24 hours, luciferase activity was measured. Data from one (A, B) or two (C, D) independent experiments are shown. See also Figure S5