FIGURE 1.

Levels of eicosanoids in the BAL fluids of healthy and COVID‐19 patients. BALs were obtained and processed as described in Methods. Lipids then were extracted and quantitated by LC‐MS/MS. A, Metabolism of arachidonic acid (AA) by the cyclooxygenase (COX) pathway. B, AA levels. C,D, Levels of COX‐derived metabolites. E, Leukotriene (LT) biosynthetic pathways. F,G, Levels of LTs and eoxins (EX). H, Metabolism of AA and eicosapentaenoic acid (EPA) by 5‐, 12‐, and 15‐lipoxygenase (LO). I,J, Levels of LO‐derived metabolites of AA. K, EPA levels. L, Levels of LO‐derived EPA metabolites. L, Proportions of eicosanoids from panel C, D, F, G, I, and K. Results are from the BALs of 25 healthy subjects and 33 COVID‐19 patients. P values were obtained by performing a Mann‐Whitney test using the GraphPad Prism 9 software: *** = P < .001, **** = P < .0001