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. 2021 Jun 2;12:658896. doi: 10.3389/fimmu.2021.658896

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Copyright © 2021 Lange, Lange and Jaskuła

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Post-alloHSCT chain of events affecting immune system competence. (A) Post-alloHSCT toxicity induces a pro-inflammatory environment with an increase in blood monocytic-marrow derived suppressor cells (CD14+HLADR-) (8), (B) Herpes viruses reactivate (CMV reactivation events in post-transplant period) (28, 29), in the peripheral blood lymphocytes CD8+CD57+ cells increase (110) – T cell repertoire skewed to highly differentiated T cells effective against chronic infection epitopes but neglecting new challenges, (C) TCR gamma/delta cells reprogrammed by CMV reactivation appear frequently in the blood (prevalence of deltaV2 negative cells) (111), immunodominant clones expand (93).