AE |
Adverse event |
ANG2 |
Angiopoietin-2 |
APC |
Antigen-presenting cell |
CCL2 |
C-C motif chemokine ligand 2 |
CCL20 |
C-C motif chemokine ligand 20 |
CCL22 |
C-C motif chemokine ligand 22 |
CCL28 |
C-C motif chemokine ligand 28 |
CIK |
Cytokine-induced killer cell |
CSF1 |
Colony stimulating factor 1 |
CTLA4 |
Cytotoxic T-lymphocyte-associated protein 4 |
CXCL12 |
C-X-C motif chemokine ligand 12 |
CXCR4 |
C-X-C motif chemokine receptor 4 |
DC |
Dendritic cell |
EC |
Endothelial cell |
EMA |
Exponential moving average |
FDA |
Food and Drug Administration |
FGFR |
Fibroblast growth factor receptor |
GBM |
Glioblastoma multiforme |
GM-CSF |
Granulocyte-macrophage colony stimulating factor |
HCC |
Hepatocellular carcinoma |
HIF-1α |
Hypoxia-inducible factor 1-alpha |
HPV |
Human papillomavirus |
ICAM1 |
Intercellular adhesion molecule 1 |
ICB |
Immune checkpoint blockade |
ICI |
Immune checkpoint inhibitor |
IDO |
Indoleamine 2,3-dioxygenase |
IFN-γ |
Interferon-gamma |
IL-10 |
Interleukin-10 |
IL-6 |
Interleukin-6 |
imDC |
Immature dendritic cell |
Jak2/STAT3 |
Janus kinase 2/Signal transducer and activator of transcription 3 |
MDSC |
Myeloid-derived suppressive cell |
MHC |
Major histocompatibility complex |
NF-κB |
Nuclear factor κB |
Nrp-1 |
Neuropilin 1 |
NSCLC |
Non-small cell lung cancer |
ORR |
Objective response rate |
OS |
Overall survival |
PD-1 |
Programmed cell death-1 |
PDGFR |
Platelet-derived growth factor receptor |
PD-L1 |
Programmed death ligand 1 |
PFS |
Progress-free survival |
PGE2 |
Prostaglandin E2 |
PI3K |
Phosphoinositide-3-kinase |
PIGF |
Placental growth factor |
PLCγ |
Phospholipase C gamma |
RTK |
Receptor tyrosine kinase |
SDF-1α |
Stromal-cell-derived factor 1 alpha |
TAM |
Tumor associated macrophage |
TGF-β |
Transforming growth factor beta |
TKI |
Tyrosine kinase inhibitor |
TMB |
Tumor burden |
TME |
Tumor microenvironment |
TPS |
Tumor proportion score |
Tregs |
Regulatory T cells |
VCAM1 |
Vascular cell adhesion protein 1 |
VEGF |
Vascular endothelial growth factor |
VEGFR |
Vascular endothelial growth factor receptor |