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Cumulative in vitro release of 4-AP from PLGA–PEG in PBS (pH 7.4) at 37 °C. PLGA–PEG carriers exhibited an overall burst biphasic profile with a burst release of 4-AP within 1 day followed by release of a low maintenance dose for approximately 28 days. Cumulative release was proportional to total loaded amount of 4-AP. Data are expressed as means ± SEM, n = 3/group.
