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. Author manuscript; available in PMC: 2021 Jun 16.
Published in final edited form as: ACS Appl Bio Mater. 2021 Apr 19;4(5):4140–4151. doi: 10.1021/acsabm.0c01566

Figure 8.

Figure 8.

Effects of (4-AP)–PLGA–PEG on immunohistochemical markers of nerve regeneration. (A) Representative transverse sciatic nerve immunofluorescent images of nuclei (DAPI), NF-H, and MPZ on post-injury day 28. Each image represents nine images from three different mice. Scale bar: 50 μm; magnification: 20×. (B) Quantification of NF-H integrated density on post-injury day 28. (4-AP)–PLGA–PEG-treated nerves contained significantly more NF-H protein in the lesion area than nerves from saline-treated animals. (C) Quantification of MPZ integrated density on post-injury day 28. (4-AP)–PLGA–PEG-treated nerves contained significantly more MPZ in the lesion area than nerves from saline-treated animals. Data are expressed as means ± SEM, **p < 0.01 and ***p < 0.001 vs saline group, n = 3/group.