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. Author manuscript; available in PMC: 2021 Jun 16.
Published in final edited form as: Cell Metab. 2017 Jun 6;25(6):1348–1361.e8. doi: 10.1016/j.cmet.2017.05.006

Figure 6. α Cell Mass Is Reduced in Slc38a5;Gcgr Double Knockout Mice.

Figure 6.

(A–D) Blood glucose (A), amino acids (B), plasma glucagon (C), and insulin (D) levels of wild-type (WT), Gcgr−/−, Slc38a5−/−, and Slc38a5;Gcgr double knockout (DKO) mice. Data are mean ± SEM, n = 5–12. *p < 0.05, ***p < 0.001, ****p < 0.0001.

(E) Glucagon (red), Slc38a5 (green), and DAPI nuclei (blue) immunofluorescence staining of pancreas sections from WT, Gcgr−/−, Slc38a5−/−, and DKO mice.

(F–I) α cell mass (F), α cell size (G), β cell mass (H), and islet number per pancreas section (I) in WT, Gcgr−/−, Slc38a5−/−, and DKO mice. Data are mean ± SEM, n = 4–11. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.