FIGURE 7.

Deregulations of gnathostome-specific hubs of the JDN are more frequent associated with invasive and metastatic stages, as opposed to pre-gnathostome hubs. (A) Functional interaction network (confidence interaction score ≥ 0.9) of the gnathostome-specific and pre-gnathostome JIG hubs. The size of the nodes is proportional to the node degree in the “original” JDN network in Figure 3d. The 60 nodes that represent intra- and inter-modular hubs in the original network appear to be interconnected and form a rather dense network. (B) The gnathostome-specific genes make up 52% (159) of all 305 JIGs (outer ring “JIG total,” red), whilst the proportion of gnathostome hubs is significantly enriched in relation to the pre-gnathostome (inner circle “hubs,” red). (C) More gnathostome-specific hubs that are deregulated in CCLE cells are correlated with worse prognosis in PanCan cohort (ring “bad hubs,” red). In contrast, more pre-gnathostome hubs tend to correlate with favorable than poor prognosis (compare ring “bad hubs” with inner circle “good hubs,” green). (D) More gnathostome-specific hubs are found deregulated, compared to the pre-gnathostome ones, in metastatic lesions (inner ring). This preference is more pronounced for hubs commonly deregulated in metastatic samples and CCLE cells (inner circle).