Fig. 5.

Central role of arginine metabolism in changes in the cerebrospinal fluid and serum metabolomes of neonatal sepsis with meningoencephalitis. Changes in arginine metabolism were closely related to changes in creatinine metabolism, as well as changes in oxidative stress-related markers and potentially harmful bile acid and aromatic compound metabolism. Metabolites in red/blue were enriched/decreased in neonatal sepsis with meningoencephalitis. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.) (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)