Table 2.
Adjuvant therapy and tumour characteristics for patients with oestrogen receptor positive, clinically node negative breast cancer (N = 253).
| Tumour characteristics | Age 66-70 (n = 99, 39.1%) | Age 71-75 (n = 75, 29.7%) | Age > 75 (n = 79, 31.2%) | Total | P-value |
|---|---|---|---|---|---|
| Grade | .294 χ2 | ||||
| 1 | 7 (7.1%) | 5 (6.6%) | 3 (3.8%) | 15 (5.9%) | |
| 2 | 75 (75.6%) | 59 (78.7%) | 70 (88.6%) | 204 (80.6%) | |
| 3 | 17 (17.3%) | 11 (14.7%) | 6 (7.6%) | 34 (13.4%) | |
| Tumour stage | .093† | ||||
| 1 | 55 (55.6%) | 35 (46.7%) | 31 (39.8%) | 121 (47.8%) | |
| 2 | 44 (44.4%) | 40 (54.3%) | 48 (60.2%) | 132 (52.2%) | |
| Histological subtype | .906 χ2 | ||||
| IDC | 81 (81.8%) | 58 (77.3%) | 64 (81.0%) | 203 (80.2%) | |
| ILC | 15 (15.1%) | 15 (20.0%) | 12 (15.2%) | 42 (16.6%) | |
| Other | 3 (3.0%) | 2 (2.7%) | 3 (6.3%) | 8 (3.2%) | |
| Oncotype DX Group (n = 82) | .573 χ2 | ||||
| Low risk (< 11) | 6 (14.0%) | 2 (10.0%) | 5 (26.3%) | 13 (15.9%) | |
| Intermediate risk (11-25) | 28 (65.1%) | 12 (60.0%) | 11 (57.9%) | 51 (62.2%) | |
| High risk (> 25) | 9 (20.9%) | 6 (30.0%) | 3 (15.8%) | 18 (22.0%) | |
| Surgery | .462† | ||||
| BCS | 84 (38.4%) | 68 (31.1%) | 67 (30.6%) | 219 (86.6%) | |
| Mastectomy | 15 (44.1%) | 7 (20.6%) | 12 (35.3%) | 34 (13.4%) | |
| Adjuvant chemotherapy | <.001* χ2 | ||||
| Underwent treatment | 31 (31.3%) | 15 (20.0%) | 5 (6.3%) | 51 (20.2%) | |
| Did not undergo treatment | 68 (68.7%) | 60 (80.0%) | 74 (93.7%) | 202 (79.8%) | |
| Adjuvant radiotherapy | .184 χ2 | ||||
| Underwent treatment | 70 (70.7%) | 56 (74.7%) | 48 (60.8%) | 173 (68.4%) | |
| Did not undergo treatment | 29 (28.3%) | 19 (25.3%) | 31 (39.2%) | 80 (31.6%) | |
| Completion ALND | .973 χ2 | ||||
| Underwent treatment | 92 (92.9%) | 69 (92.0%) | 73 (92.4%) | 234 (92.5%) | |
| Did not undergo treatment | 7 (7.1%) | 6 (8.0%) | 6 (7.6%) | 19 (7.5%) | |
Abbreviations: ALND, axillary lymph node dissection; BCS, breast conserving surgery; IDC, invasive ductal carcinoma; ILC, invasive lobular carcinoma.
χ2 denotes chi-square test.
†
denotes Fisher’s exact test.
*
denotes statistical significance.