Table 1.
Baseline demographic and biochemical characteristics according CKD stages
| Baseline characteristics CKD stages mGFR |
Total n = 858 | 1 - 2 |
3a |
3b |
4 - 5 |
P value |
|---|---|---|---|---|---|---|
| ≥ 60 ml/min |
45-60 ml/min |
30-45 mL/min |
< 30 mL/min |
|||
| n = 156 | n = 203 | n = 262 | n = 237 | |||
| Age (yr) | 58.9±15.2 | 50.8±15.7 | 59.8±13.2 | 61.1±14.8 | 61.1±15.1 | 0.061 |
| Weight (kg) | 75.5±16.5 | 74.6±17.1 | 74.5±15.1 | 75.4±16.8 | 77.1±18.1 | 0.339 |
| Height (cm) | 167.6±9.2 | 168.7±8.4 | 168.2±8.8 | 166.9±9.7 | 167.0±9.6 | 0.134 |
| Intact PTH (pg/ml)a | 57.0(38.0;90.0) | 37.0(26.0;48.2) | 48.0(34.5;66.5) | 62.0(43.0;89.8) | 101.0(68.0;164.0) | < 0.001 |
| ionized calcium (mmol/l)a | 1.23(1.20;1.27) | 1.23(1.20;1.26) | 1.23(1.21;1.27) | 1.23(1.21;1.27) | 1.24(1.20;1.27) | 0.87 |
| serum calcium (mmol/l)a | 2.27(2.20;2.34) | 2.27(2.21;2.34) | 2.28(2.22;2.35) | 2.27(2.21;2.34) | 2.25(2.17;2.32) | < 0.01 |
| corrected calcium (mmol/l)a | 2.29(2.23;2.37) | 2.27(2.21;2.33) | 2.28(2.24;2.37) | 2.31(2.24;2.37) | 2.29(2.21;2.37) | < 0.05 |
| serum magnesium (mmol/l)a | 0.79(0.73;0.85) | 0.77(0.73;0.82) | 0.78(0.73;0.84) | 0.79(0.74;0.84) | 0.81(0.74;0.88) | < 0.05 |
| serum phosphate (mmol/l) | 1.05(0.93;1.17) | 1.02(0.90;1.13) | 0.99(0.89;1.09) | 1.03(0.93;1.14) | 1.15(1.03;1.34) | < 0.001a |
| 25(OH)-vitamin D (ng/ml) | 21.9±12.2 | 20.9±11.5 | 22.8±11.2 | 22.7±13.1 | 21.0±12.2 | 0.066b |
| Calcitriol (pg/ml)a | 20.0(12.5;28.8) | 43.2(31.0;55.2) | 36.2(27.5;45.7) | 31.0(22.9;40.4) | 21.7(15.0;30.0) | < 0.001 |
| BS-ALP (ng/ml)a | 13.6(10.1;18.4) | 13.4(10.2;17.8) | 13.7(10.2;17.5) | 13.7(10.1;19.4) | 13.3(10.0;19.2) | 0.824 |
| uric acid (μmol/l) | 405.7±99.8 | 354.8±83.3 | 399.8±91.8 | 423.4±97.5 | 424.4±106.9 | < 0.001b |
| serum crosslaps (nmol/l)a | 516.1(258.1;774.2) | 258.1(258.1;387.1) | 387.1(258.1;645.2) | 516.1(258.1;645.2) | 774.2(387.1;1064.5) | < 0.001 |
CKD, chronic kidney disease; mGFR, measured glomerular filtration rate; PTH, parathyroid hormone; BS-ALP, bone specific alkaline phosphatases.
Results are expressed as mean±standard deviation. An ANOVA was conducted following by a Tukey’s test as a posteriori multiple comparisons when p-value <0.05
a
Median (25th through 75th percentile) compared by a Kruskall-Wallis' test following by a Steel-Dwass-Critchlow-Fligner’s test. as a posteriori multiple comparisons when P value <0.05.
b
Analysis of variance test with log transformation of the variable.