Table 2.
Baseline BMD measurements according CKD stages
| Skeletal sites | CKD stages mGFR | Total n = 858 | 1 - 2 |
3a |
3b |
4 - 5 |
P value |
|---|---|---|---|---|---|---|---|
| ≥ 60 ml/min |
45-60 ml/min |
30-45 ml/min |
< 30 ml/min |
||||
| n = 156 | n = 203 | n = 262 | n = 237 | ||||
| Femoral neck | BMD (g/cm2) | 0.87±0.16 | 0.94 ± 0.17 | 0.89 ± 0.15 | 0.87 ± 0.16 | 0.83 ± 0.14 | <0.0001 |
| Z-score | 0.20±1.08 | 0.40±1.16 | 0.30±1.08 | 0.26±1.04 | -0.11±1.00 | <0.0001 | |
| T-scorea | -0.9(-1.7;-0.01) | -0.28(-1.10;0.70) | -0.80(-1.60;0.10) | -1.00(-1.70;-0.06) | -1.28(-1.91;-0.53) | <0.0001 | |
| Total hip | BMD (g/cm2) | 0.97±.017 | 1.02 ± 0.17 | 0.98 ± 0.17 | 0.96 ± 0.17 | 0.93 ± 0.16 | <0.0001 |
| Z-score | 0.39±1.11 | 0.50±1.12 | 0.46±1.08 | 0.46±1.13 | 0.18±1.10 | <0.05 | |
| T-score | -0.25±1.22 | 0.20±1.29 | -0.17±1.20 | -0.29±1.21 | -0.55±1.12 | <0.0001 | |
| Lumbar spine | BMD (g/cm2) | 1.08±0.18 | 1.09 ± 0.17 | 1.11 ± 0.19 | 1.08 ± 0.19 | 1.05 ± 0.18 | <0.05 |
| Z-score | 0.11±1.54 | -0.12±1.42 | 0.36±1.47 | 0.20±1.58 | -0.06±1.59 | <0.01 | |
| T-score | -0.48±1.58 | -0.38±1.50 | -0.25±1.59 | -0.49±1.66 | -0.73±1.48 | <0.05 | |
| Proximal radius | |||||||
| Hologic | BMD (g/cm2) | 0.50 ± 0.12 | 0.51 ± 0.11 | 0.51 ± 0.10 | 0.50 ± 0.13 | 0.50 ± 0.12 | 0.764b |
| Z-score | 0.59 ± 1.42 | 0.48 ± 1.36 | 0.66 ± 1.37 | 0.72 ± 1.46 | 0.44 ± 1.45 | 0.318 | |
| T-score | -0.60 ± 1.52 | -0.46 ± 1.51 | -0.51 ± 1.48 | -0.54 ± 1.60 | -0.77 ± 1.47 | 0.357 | |
| GE-Lunar | BMD (g/cm2) | 0.89 ± 0.12 | 0.91 ± 0.11 | 0.91 ± 0.12 | 0.88 ± 0.12 | 0.85 ± 0.15 | <0.05 |
| Z-score | -0.31 ± 1.08 | -0.49 ± 0.98 | -0.12 ± 0.99 | -0.26 ± 1.11 | -0.35 ± 1.23 | 0.219 | |
| T-score | -0.76 ± 1.13 | -0.57 ± 1.07 | -0.61 ± 1.01 | -0.87 ± 1.15 | -1.03 ± 1.25 | <0.05 | |
| Bone statusc | normal (n, %) | 473 (56%) | 104 (66%) | 122 (61%) | 139 (53%) | 108 (46%) | <0.01d |
| osteopenia (n, %) | 283 (33%) | 37 (24%) | 59 (29%) | 94 (36%) | 93 (40%) | ||
| osteoporosis (n, %) | 96 (11%) | 15 (10%) | 20 (10%) | 28 (11%) | 33 (14%) |
CKD, chronic kidney disease; BMD, bone mineral density; mGFR, measured glomerular filtration rate.
Results are expressed as mean ± SD. An analysis of variance was conducted following by a Tukey’s test as a posteriori multiple comparisons when P value <0.05
a
Median (25ththrough 75thpercentile) compared by a Kruskall-Wallis test following by a Steel-Dwass-Critchlow-Fligner test as a posteriori multiple comparisons when P value <0.05.
b
Aanlysis of variance test with log transformation of the variable.
c
According to World Health Organization definition including T-score at L1-L4 and Total Hip.
d
Chi-square test.