Table 2.

Teaching points regarding BK virus nephropathy in the native kidney

BK virus nephropathy (BKVN) can occur in the native kidney in immunosuppressed states, most notably hematologic malignancies and nonrenal solid organ transplantation

BKVN has been described in the native kidney in liver, lung, cardiac, and pancreas transplant recipients. In this setting, even with reduction in immunosuppression, BKVN has a poor prognosis with respect to renal functional recovery

Similar to the kidney allograft, BKVN in the native kidney is characterized by findings of tubulointerstitial nephritis with interstitial lymphocytes and plasma cells, accompanied by intranuclear viral inclusion