Figure 2.

Overview of monocyte kinetics in health and inflammation. Under steady physiological conditions, classical monocytes arise from cMoP and reside within the bone marrow for approximately 1·6 days before being released into the circulation. Once within the circulation, these cells mature into intermediate and then non‐classical monocytes, which circulate for 4 and 7 days, respectively. During systemic inflammation, classical monocytes are rapidly released into the circulation. Following local injury, classical monocytes are initially recruited later followed an intermediate monocyte phenotype, although the origin of the cells is unknown (dashed lines). HSC, haematopoietic stem cell; cMoP, common monocyte progenitor.