Table 1.
Baseline characteristics of patients based on anticoagulation status (therapeutic/supra-therapeutic vs. sub-therapeutic).
| Therapeutic INR (n = 160) | Sub-therapeutic INR ( n = 222) | p-value | |
|---|---|---|---|
| Age (years, mean ± SD) | 77.6 ± 11.6 | 77.3 ± 10.5 | 0.769 |
| Male sex (n, %) | 87, 54.4% | 113, 50.9% | 0.502 |
| Hypertension (n, %) | 138, 86.3% | 181, 81.5% | 0.220 |
| Diabetes (n, %) | 57, 35.6% | 85, 38.3% | 0.595 |
| Hyperlipidemia (n, %) | 93, 58.1% | 126, 56.8% | 0.790 |
| Prior Stroke or TIA (n, %) | 72, 45.0% | 79, 35.6% | 0.063 |
| Known active cancer (n, %) (n = 366) | 14, 9.2% | 13, 6.1% | 0.271 |
| CHA2DS2-Vasc listed as median (IQR) | 5 (3) | 5 (2) | 0.450 |
| Antiplatelet therapy (n, %) | 71, 44.4% | 54, 24.3% | <0.001 |
| Statin therapy (n, %) | 94, 58.8% | 138, 62.2% | 0.525 |
| Systolic blood pressure (mm Hg, mean ± SD) | 147.1 ± 29.1 | 147.6 ± 30.0 | 0.892 |
| Diastolic blood pressure (mm Hg, mean ± SD) | 77.6 ± 17.7 | 81.6 ± 19.4 | 0.040 |
| Glucose level on admission (mg/dL, mean ± SD) | 135.6 ± 52.6 | 138.9 ± 57.8 | 0.573 |
| Low density lipoprotein level (md/dL, mean ± SD) | 78.5 ± 32.1 | 81.9 ± 31.9 | 0.318 |
| NIHSS score listed as median (IQR) | 8 (16) | 11 (16) | 0.196 |
| Troponin positive (n, %) (n=290) | 16, 12.4% | 19, 11.8% | 0.876 |
| Ipsilateral Atherosclerosis ≥50% (n, %) (n=353) | 30, 19.9% | 24, 11.9% | 0.039 |
| Ischemic lesion < 10 mL (n, %) (n=322) | 71, 52.2% | 70, 37.6% | 0.009 |
| Severe left atrial enlargement (n, %) (n=268) | 55, 51.4% | 75, 46.6% | 0.440 |
| Spontaneous echocardiographic contrast/thrombus (n, %) (n=327) | 3, 2.2% | 9, 4.7% | 0.535 |