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. Author manuscript; available in PMC: 2021 Dec 1.
Published in final edited form as: Neuropharmacology. 2020 Sep 17;180:108296. doi: 10.1016/j.neuropharm.2020.108296

Figure 6. Sex differences in CRF regulation of excitability in CRF1+, but not CRF1-, CeA neurons.

Figure 6.

(A) Representative cell-attached recording of male (left) and female (right) CRF1+ CeA neurons during focal application of aCSF (top) and CRF (200nm; bottom). (B) Quantification of cell-attached firing frequency in male and female CRF1+ CeA neurons following focal application of aCSF and CRF (200nM) expressed in Hz (left) and percent of control (right). (C) Representative cell-attached recording of male (left) and female (right) CRF1+ CeA neurons during bath superfusion of DNQX, APV and CGP with focal application of aCSF (top) and CRF (200nm; bottom). (D) Quantification of cell-attached firing frequency in male and female CRF1+ CeA neurons following focal application of aCSF and CRF (200nM) in the presence of DNQX, APV and CGP expressed in Hz (left) and percent of control (right). (E) Representative cell-attached recording of male (left) and female (right) CRF11 CeA neurons during focal application of aCSF (top) and CRF (200nm; bottom). (F) Quantification of cell-attached firing frequency in male and female CRF1- CeA neurons following focal application of aCSF and CRF (200nM) expressed in Hz (left) and percent of control (right). ** = p < 0.01 by two-sample t-test, # = p < 0.05 by one-sample t-test, ## = p < 0.01 by one-sample t-test, [***] = p < 0.001 by Sidak’s multiple comparison’s test.