Table 3.
Causal network analysis utilizing SOD1G93A Agerfl/fl Cx3cr1Cre/+ and SOD1G93A Ager+/+ Cx3cr1Cre/+ differentially expressed genes
| Cytokine | Z-Score (activation score) | FDR |
|---|---|---|
| CXCL1 | 3.464 | 5.48E-05 |
| CXCL9 | 3.317 | 1.24E-04 |
| IL3 | 3.286 | 1.98E-08 |
| TSLP | 3.266 | 5.78E-12 |
| IL5 | 2.985 | 4.36E-07 |
| IFNA1/IFNA13 | 2.837 | 4.26E-08 |
| IL22 | 2.828 | 4.09E-06 |
| CD70 | 2.828 | 8.82E-05 |
| IL1A | 2.4 | 9.75E-06 |
| IL15 | 1.569 | 9.70E-08 |
| WNT1 | 1.414 | 6.43E-12 |
| IFNB1 | 1.183 | 1.29E-11 |
| TNFSF10 | 0.365 | 8.95E-09 |
| IL6 | 0.333 | 2.89E-04 |
| TNFSF12 | -1 | 9.70E-04 |
Results of IPA predicted causal network regulators, which are labeled as “cytokine”. Positive values indicate predicted activation in SOD1G93A Ager+/+ Cx3cr1Cre/+ mice