Table 2.
Von Willebrand factor quartiles and mortality
| Total N=956 |
Mean level (ug/mL) | Mortality rate per 1000 patient years |
Crude HR (95% CI) |
Adjusteda HR (95% CI) |
|||
|---|---|---|---|---|---|---|---|
| All-cause mortality | |||||||
| Quartile 1 | 239 | 9.4 | 99 | reference | reference | ||
| Quartile 2 | 239 | 15.4 | 129 | 1.3 | (0.9-1.9) | 1.2 | (0.8-1.7) |
| Quartile 3 | 239 | 21.0 | 172 | 1.7 | (1.2-2.5) | 1.5 | (1.1-2.2) |
| Quartile 4 | 239 | 36.2 | 209 | 2.1 | (1.5-3.0) | 1.8 | (1.2-2.6) |
| Quartile 4 versus Quartile 1-3 | 1.6 | (1.2-2.0) | 1.4 | (1.1-1.8) | |||
| Cardiovascular mortality | |||||||
| Quartile 1 | 239 | 9.4 | 51 | reference | reference | ||
| Quartile 2 | 239 | 15.4 | 73 | 1.4 | (0.8-2.3) | 1.3 | (0.8-2.1) |
| Quartile 3 | 239 | 21.0 | 82 | 1.6 | (1.0-2.6) | 1.4 | (0.9-2.4) |
| Quartile 4 | 239 | 36.2 | 102 | 2.0 | (1.2-3.3) | 1.7 | (1.0-2.8) |
| Quartile 4 versus Quartile 1-3 | 1.5 | (1.1-2.1) | 1.3 | (0.9-1.9) | |||
| Non-cardiovascular mortality | |||||||
| Quartile 1 | 239 | 9.4 | 47 | reference | reference | ||
| Quartile 2 | 239 | 15.4 | 56 | 1.2 | (0.7-2.1) | 1.1 | (0.6-1.9) |
| Quartile 3 | 239 | 21.0 | 90 | 1.9 | (1.2-3.2) | 1.6 | (1.0-2.8) |
| Quartile 4 | 239 | 36.2 | 107 | 2.3 | (1.4-3.7) | 1.9 | (1.1-3.3) |
| Quartile 4 versus Quartile 1-3 | 1.7 | (1.2-2.4) | 1.5 | (1.0-2.2) | |||
aAdjusted for age, sex, body mass index, cardiovascular disease, dialysis modality, smoking, primary kidney disease, use of antithrombotic medication, systolic blood pressure, albumin, C-reactive protein and residual GFR