Table 3.
ADAMTS13 quartiles and mortality
| Total N=956 |
Mean level (activity %) | Mortality rate per 1000 patient years |
Crude HR (95% CI) |
Adjusteda HR (95% CI) |
|||
|---|---|---|---|---|---|---|---|
| All-cause mortality | |||||||
| Quartile 1 | 239 | 16.7 | 181 | 1.3 | (1.0-1.8) | 1.2 | (0.9-1.7) |
| Quartile 2 | 239 | 33.0 | 156 | 1.1 | (0.8-1.6) | 0.9 | (0.7-1.3) |
| Quartile 3 | 239 | 45.7 | 132 | 1.0 | (0.7-1.4) | 0.9 | (0.6-1.2) |
| Quartile 4 | 239 | 68.1 | 136 | reference | reference | ||
| Quartile 1 versus Quartile 2-4 | 1.3 | (1.1-1.7) | 1.3 | (1.0-1.7) | |||
| Cardiovascular mortality | |||||||
| Quartile 1 | 239 | 16.7 | 88 | 1.2 | (0.8-1.8) | 1.1 | (0.7-1.8) |
| Quartile 2 | 239 | 33.0 | 80 | 1.1 | (0.7-1.7) | 0.9 | (0.6-1.4) |
| Quartile 3 | 239 | 45.7 | 63 | 0.8 | (0.5-1.4) | 0.8 | (0.5-1.3) |
| Quartile 4 | 239 | 68.1 | 75 | reference | reference | ||
| Quartile 1 versus Quartile 2-4 | 1.2 | (0.9-1.6) | 1.2 | (0.9-1.8) | |||
| Non-cardiovascular mortality | |||||||
| Quartile 1 | 239 | 16.7 | 92 | 1.5 | (1.0-2.4) | 1.3 | (0.8-2.2) |
| Quartile 2 | 239 | 33.0 | 76 | 1.3 | (0.8-2.0) | 1.0 | (0.6-1.6) |
| Quartile 3 | 239 | 45.7 | 69 | 1.1 | (0.7-1.9) | 1.0 | (0.6-1.6) |
| Quartile 4 | 239 | 68.1 | 61 | reference | reference | ||
| Quartile 1 versus Quartile 2-4 | 1.4 | (1.0-1.9) | 1.4 | (1.0-2.0) | |||
aAdjusted for age, sex, body mass index, cardiovascular disease, smoking, dialysis modality, primary kidney disease, use of antithrombotic medication, systolic blood pressure, albumin, C-reactive protein and residual GFR