Table 4.
Combination of ADAMTS13 and von Willebrand factor and mortality
| Total N=956 |
Mortality rate per 1000 patient years |
Crude HR (95% CI) |
Adjusteda HR (95% CI) |
|||
|---|---|---|---|---|---|---|
| All-cause mortality | ||||||
| VWF p<75 AND ADAMTS13 p>25 | 549 | 125 | reference | reference | ||
| VWF p<75 AND ADAMTS13 p≤25 | 168 | 159 | 1.3 | (0.9-1.7) | 1.2 | (0.9-1.7) |
| VWF p≥75 AND ADAMTS13 p>25 | 168 | 197 | 1.6 | (1.2-2.1) | 1.3 | (1.0-1.8) |
| VWF p≥75 AND ADAMTS13 p≤25 | 71 | 241 | 2.0 | (1.3-2.9) | 2.0 | (1.3-3.0) |
| Cardiovascular mortality | ||||||
| VWF p<75 AND ADAMTS13 p>25 | 549 | 65 | reference | reference | ||
| VWF p<75 AND ADAMTS13 p≤25 | 168 | 79 | 1.2 | (0.8-1.9) | 1.2 | (0.7-1.8) |
| VWF p≥75 AND ADAMTS13 p>25 | 168 | 99 | 1.5 | (1.0-2.3) | 1.2 | (0.8-1.9) |
| VWF p≥75 AND ADAMTS13 p≤25 | 71 | 112 | 1.8 | (1.0-3.1) | 1.8 | (1.0-3.2) |
| Non-cardiovascular mortality | ||||||
| VWF p<75 AND ADAMTS13 p>25 | 549 | 60 | reference | reference | ||
| VWF p<75 AND ADAMTS13 p≤25 | 168 | 79 | 1.3 | (0.8-2.1) | 1.3 | (0.8-2.1) |
| VWF p≥75 AND ADAMTS13 p>25 | 168 | 99 | 1.7 | (1.1-2.5) | 1.5 | (0.9-2.3) |
| VWF p≥75 AND ADAMTS13 p≤25 | 71 | 128 | 2.2 | (1.3-3.7) | 2.1 | (1.2-3.7) |
aAdjusted for age, sex, body mass index, cardiovascular disease, smoking, dialysis modality, primary kidney disease, use of antithrombotic medication, systolic blood pressure, albumin, C-reactive protein and residual GFR