Table 4.
Assays performance according to the RT-PCR assay
| Kit | Overall agreement % (95% CI) | Sensitivity % (95% CI) | Specificity % (95% CI) | PPV % (95% CI) | NPV % (95% CI) | Cohen’s Kappa value (CI) |
|---|---|---|---|---|---|---|
| Wantai HEV-Ag | 81.1 (70.7–88.4) | 36.7 (16.3–56.5) | 100.0 (100–100) | 100.00 (100–100) | 78.7 (68.9–88.7) | 0.44 (0.22–0.66) |
| Wantai HEV-IgM | 91.0 (83.8–95.2) | 71.4 (52.1–90.8) | 96.20 (91.9–100) | 83.3 (66.1–100.5) | 92.6 (87.0–98.3) | 0.71 (0.53–0.88) |
| Wantai HEV-IgG | 70.3 (60.8–78.3) | 63.64(43.5–83.7) | 72.15 (62.3–82.0) | 38.8 (22.9–54.8) | 87.6 (79.7–95.6) | 0.29 (0.10–0.48) |
| MP HEV-Total Ab | 73.2 (61.9–82.1) | 77.27 (59.8–94.8) | 71.43 (58.8–84.1) | 54.8 (37.3–72.3) | 87.5 (77.2–97.7) | 0.44 (0.23–0.64) |
The overall percent agreement is the percentage of total subjects where the new test and the non-reference standard agree
PPV positive predictive value, NPV negative predictive value