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. 2021 Jun 15;14:161. doi: 10.1186/s12920-021-01011-z

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Single nuclei RNA-sequencing reveals cellular diversity within the adult human IVS. a UMAP of the integrated dataset overlayed with cell type assignment for each cluster. b Distribution of cell types in the adult human IVS. Similar cell types were grouped together. c Dotplot of different biomarker expression across all the cell types. The size of the dot indicates the percentage of cells within that cluster expressing that gene, and the color indicates the normalized level of expression. d Qiagen Ingenuity Pathway comparison heatmap of the top canonical pathways across the five cardiomyocyte populations within the IVS. e Qiagen Ingenuity Pathway comparison heatmap of the top canonical pathways across the six fibroblast populations within the IVS