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. 2021 Jun 16;12:348. doi: 10.1186/s13287-021-02303-y

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — Bioinformatic analysis and verification of the targets of miR-20a. a Three online prediction tools such as miRWalk, Starbase and miRDB were applied for selecting the potential targets of miR-20a. Venn diagram was showed for screening of BAMBI. b The gene expression of BAMBI after treated with sEV-20a. c The predicted binding sites of miR-20a in the 3′-UTR of BAMBI-WT mRNA. d Luciferase report assay showed the luciferase activity of BAMBI-WT and BAMBI-Mu treated by miR-20a. Negative control (NC) was used as the control vector ( *p < 0.05)