Table 2.
Levels of Measured Endogenous Etheno DNA Adducts (see also [61])
| DNA Source | Adducts/108 nucleotides | Method | Reference | ||||
|---|---|---|---|---|---|---|---|
| 1,N6-ε-dAdo | 3,N4-ε-dCyd | 1,N2-ε-dGuo | N2,3-ε-dGuo | ||||
| Rat | Liver | 0.10–0.12 | 0.10–0.12 | Immunoaffinity/32P labeling | [47] | ||
| Liver | 18–23 | GC/MS | [47] | ||||
| Liver | 120 | 560 | HPLC/32P labeling | [62] | |||
| Liver | 0.011–0.012 | 0.016–0.017 | Immunoaffinity/32P labeling | [63] | |||
| Lung | 0.4–0.5 | 1.8–3.8 | Immunoaffinity/32P labeling | [63] | |||
| Kidney | 0.7–0.8 | 2.1–2.8 | Immunoaffinity/32P labeling | [63] | |||
| Lymphocytes | 1.1 | 1.2 | Immunoaffinity/32P labeling | [63] | |||
| Hepatocytes | 1.4 | Immunoaffinity/GC/MS | [64] | ||||
| Hepatocytes | NDa | Immunoaffinity/GC/MS | [65] | ||||
| Human | Hepatocytes | 2.0 | LC/MS | [66] | |||
| Oral cells | 0.77 | 0.61 | LC/MS | [67] | |||
| Placenta | 74–84 | LC/MS | [68] | ||||
| Placenta | 1.1 | LC/MS | [69] | ||||
| Pancreas | 1.8 | 1.2 | Immunoaffinity/32P labeling | [70] | |||
aND Not detected (< 4)