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. 2021 Jun 16;22:452. doi: 10.1186/s12864-021-07747-3

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Type-1 interferon pathway of DEGs in P compared to NP samples from day 18 bovine CL clustered by GSEA and IPA. (A) GSEA enrichment plot showing type-1 interferon pathway candidate genes enriched in P compared to NP bovine CL. Normalized enrichment signal (NES); Normalized p-value (NOM), False Discovery Rate (FDR). (B) Type-1 interferon pathway generated with IPA. Genes that are significantly up- and downregulated are shown in red and green, respectively. The intensity of the color corresponds to an increase or decrease in fold change between the P and NP bovine CL. The inset table indicates the expression of select ISGs in CL slices and luteal cells treated with roIFNT (1 ng/mL) in vitro, previously published