Table 1.
Baseline characteristics of normal subjects and non-diabetic first degree relatives of Type 2 DM patients
| Normal subjects (n = 39) |
FDRs of Type 2 DM (n = 64) |
p-value | |
|---|---|---|---|
| Age (years) | 31.4 ± 4.61 | 32.3 ± 5.16 | 0.373 |
| Body mass index (kg/m2) | 21.2 ± 2.52 | 22.9 ± 2.11 | 0.0004 |
| Waist Circumference (cm) | 80.9 ± 7.94 | 88.4 ± 9.2 | 2.4 × 10−5 |
| Systolic blood pressure (mmHg) | 112 ± 11 | 117 ± 11 | 0.038 |
| Diastolic blood pressure (mmHg) | 73 ± 8 | 77 ± 8 | 0.009 |
| Triglycerides (mmol/l) | 1.31 ± 0.53 | 1.98 ± 0.76 | 8.6 × 10−7 |
| HDL-cholesterol (mmol/l) | 1.15 ± 0.22 | 1.08 ± 0.19 | 0.089 |
| Fasting blood glucose (mmol/l) | 4.99 ± 0.34 | 5.19 ± 0.47 | 0.026 |
| Glycated hemoglobin (%) | 5.0 ± 0.20 | 5.3 ± 0.28 | 4.9 × 10−9 |
| Fructosamine (mmol/l) | 248 ± 39.0 | 296 ± 41.6 | 6.0 × 10−8 |
| Insulin (pmol/l) | 38 ± 13.70 | 71.1 ± 28.60 | 6.6 × 10−12 |
| HOMA-IR | 0.8 ± 0.26 | 1.5 ± 0.60 | 5.5 × 10−12 |
| HOMA-β | 85 ± 24 | 117 ± 33 | 1.3 × 10−7 |
Data are presented as means ± SD. Mean significant difference p < 0.05 bolded
HOMA-IR insulin resistance, HOMA-β β-cell function