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. 2021 Jun 15;8(5):e1027. doi: 10.1212/NXI.0000000000001027

Figure 1. Splicing Variants and Protein Isoforms of Human MOG α1-3 and β1-3.

Figure 1

(A) Exon composition of different MOG precursor transcript variants: leader = signal peptide, removed during maturation, exon 3 = contains a stop codon and is present in transcripts for soluble MOG (not depicted in this schematic), TM = encodes the single transmembrane domain, M = encodes the membrane-associated intracellular part of transcripts α1 and β1, exon 7 = specific for transcripts α3 and β3. The last 3′ exons encode specific sequences for MOGα1-3 (10a) and MOGβ1-3 (10b). (B) Protein isoforms of human MOG α1-3 and β1-3. The extracellular Ig-like domain is present in all isoforms (gray), whereas the specific intracellular composition is shown slightly enlarged within the dashed circles using colors fitting to the coding exons described above. MOG = myelin oligodendrocyte glycoprotein.