Fig. 7.

MyD88 contributed to SNHG16-mediated cancer stem cell transition in vivo. SHG44 and U251 cells that stable expressed si-MyD88 were incubated with exosomes from CSCs transfected with SNHG16 or NC, and then SHG44 and U251 cells were injected into nude mice (n = 10). A, B Tumor growth curve in nude mice. n = 10, *p < 0.05. C, D Representative tumors and tumor weight. n = 4, *p < 0.05. E Immunofluorescence staining for Ki67 expression. Scale bar = 50 μm. n = 4, *p < 0.05. F EMSA for NFκB activities. n = 4, *p < 0.05. G Western blotting for c-Myc expression. n = 4, *p < 0.05