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. 2021 Jun 15;19:184. doi: 10.1186/s12951-021-00931-3

Fig. 10.

Fig. 10

In vivo distribution of IR780-labeled Lipo or IR780-labeled Cy-Lipo in major organs of choriocarcinoma tumor-bearing nude mice during 24 h (a). Blood collection from rats by automatic blood sampling device in pharmacokinetic research (b). Drug-time curves of MTX formulations in SD rats after intravenous administration (c). Biodistribution of MTX in mice at 2 h (d), 8 h (e), and 24 h (f) after intravenous injection of MTX formulations. *P < 0.05, **P < 0.01, vs free MTX. #P < 0.05, vs Lipo@MTX