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. 2021 Jun 15;19:184. doi: 10.1186/s12951-021-00931-3

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Flow cytometry profiles of JEG-3 cells that were incubated with culture medium, Dox-labeled Lipo or Dox-labeled Cy-Lipo for 4 h (a). Confocal images of JEG-3 cells incubation with Dox-labeled Lipo or Dox-labeled Cy-Lipo for 1 h and 4 h. The nucleus of cells was stained with DAPI (blue) (b). Computational ENT1 docking analysis. Docking of Cy inside the special binding sites of ENT1 (c) and the residue interaction between ENT1 and Cy (d)