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. 2021 Jun 15;19:184. doi: 10.1186/s12951-021-00931-3

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Influence of ENT1 substrates (a) or endocytosis inhibitors (b) on cellular uptake of Dox-labeled Lipo or Dox-labeled Cy-Lipo. *P < 0.05, **P < 0.01, vs cells without pre-treatment with deoxycytidine or gemcitabine. ^#P < 0.05, ^##P < 0.01, vs cells without pre-treatment with endocytosis inhibitors. The variations of membrane (c) and cytosol (d) ENT1 protein expression after treatments with Cy-Lipo over 24 h. Analysis of ENT1 mRNA in JEG-3 cells after incubation with Cy-Lipo over 24 h (e). *P < 0.05, **P < 0.01, vs cells without treatment with Cy-Lipo