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. 2021 Jun 15;19:184. doi: 10.1186/s12951-021-00931-3

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 8 — The viability of JEG-3 (a) and Pricell-0051 cells (b) after being treated with free MTX, physical mixture of MTX and Cy-lipid, Lipo@MTX, or Cy-Lipo@MTX for 48 h during a certain drug concentration range. The effect of ENT1 competitive inhibitors on MTX formulations induced cytotoxicity (c, d). *P < 0.05, **P < 0.01, vs cells without pre-treatment with deoxycytidine or gemcitabine. Cell cycle distribution induced by culture medium or MTX formulation-contained medium for 24 h (e). Quantitative analysis of apoptosis after treating JEG-3 cells with culture medium or MTX formulation-contained medium for 24 h (f). **P < 0.01, vs Cy-Lipo@MTX group