Table 2.

Main parameters of MTX formulations after vein injection in rats

Parameters	Free MTX	Lipo@MTX	Cy-Lipo@MTX
AUC0-t (μg·h/mL)	62.42 ± 21.51	160.22 ± 47.02*	134.27 ± 18.19*
MRT(0-t) (h)	6.27 ± 2.52	17.52 ± 2.47**	17.63 ± 0.33**
t1/2β (h)	5.23 ± 2.72	12.60 ± 1.51*	13.23 ± 0.41*
Vss (mg/kg/(mg/mL))	0.58 ± 0.10	0.60 ± 0.26	0.70 ± 0.08
CL (L/h)	0.086 ± 0.03	0.032 ± 0.01*	0.037 ± 0.005*
Cmax (μg/mL)	13.52 ± 1.96	7.49 ± 1.45*	6.79 ± 1.25**

^*P < 0.05, **P < 0.01, vs free MTX