Table 3. Concentration (μg/ml) of valproate in plasma, CSF and brain.

P4 and non-pregnant female adult rats. collected 30 minutes after a single intraperitoneal injection of 30mg/kg or 100mg/Kg valproate; measured by LC–MS. Mean± SD. n=3–4. ^* Johannessen & Johannessen, (2003). Clinical dose range 20–60 mg/kg: The Australian Medicines Handbook, US Food and Drug Administration (2016) .

Injected dose	Concentration (μg/mL)
	Plasma	CSF	Cortex
P4 30 mg/kg	67 ± 12	25 ± 1	17 ± 2
P4 100 mg/kg	141 ± 6	80 ± 6	79 ± 11
Adult 30 mg/kg	34± 8	3± 1	5± 1
Adult 100 mg/kg	166 ± 28	36 ± 3	29 ± 6
Clinical plasma range	40 – 100 *	-	-