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. Author manuscript; available in PMC: 2021 Jun 16.
Published in final edited form as: J Neuroimmune Pharmacol. 2019 Jun 17;14(3):391–400. doi: 10.1007/s11481-019-09859-w

Fig. 2: JHU083 Delivers μM DON to the Brain and Reverses EcoHIV-Induced Cognitive Deficits.

Fig. 2:

A) JHU083 (1.83 mg/kg, i.p) delivered μM concentrations of DON to the brains of EcoHIV-infected mice with a Cmax of 1.19 nmol/g and AUC0-∞ of 3.7 nmol*h/g (n=3/time point). B) JHU083 administration reversed EcoHIV-induced cognitive deficits in contextual CF recall (n=17-19/group) and C) normalized RAWM performance as measured by errors made during learning trials (LT) and retention trial (RT) (n=8/group). D) No significant effect was found for EcoHIV infection or JHU083 treatment on ability to swim to a visible platform (n=8/group). *p < 0.05, ****p < 0.0001 EcoHIV+Veh vs. Sham+Veh, #p < 0.05 EcoHIV+JHU083 vs. Sham+Veh, ^p < 0.05 Sham+JHU083 vs. Sham+Veh.