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. Author manuscript; available in PMC: 2021 Nov 17.
Published in final edited form as: Nat Metab. 2021 May 17;3(5):604–617. doi: 10.1038/s42255-021-00389-5

Figure 2: The UCP1 catabolic circuit controls inflammation and myeloid cell populations in the liver.

Figure 2:

a, Protein abundance differences between WT and UCP1KO liver immune cell markers following 14 weeks WD feeding (WT n = 5; UCP1KO n = 6).

b, c, Cytofluorimetric dot plots (right) and fraction of CD45+ cells for each indicated population (left) from livers of WT and UCP1KO mice following 14 weeks on WD (b: WT n = 10; UCP1KO n = 13; c: n = 9).

d, Relative gene expression of cytokine, chemokine, and macrophage markers in WT and UCP1KO livers following 14 weeks WD (n = 10 except Il6, Il12p40, Nos2 n = 9) or chow (n = 5 except Il1, Tnf, Nos2 n = 4) feeding.

*P < 0.05, **P<0.01, ***P<0.001 (one- or two-tailed Student’s t-test for pairwise comparisons, one-way ANOVA for multiple comparisons involving two independent variables). Data are mean ± s.e.m. See source data for precise p values.