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Effects of entinostat on MDSCs. Entinostat inhibits the VEGF, ErbB and mTOR pathways in PMN-MDSCs, thereby inhibiting the activity of STAT3, which in turn reduces the activities of Arg-1, iNOS and COX2. Entinostat therapy inhibits the transport of M-MDSCs from bone marrow to the tumor environment by downregulating CCR2 expression.
