Table 1.
Effects of HDACIs on MDSCs.
| HDACI | Classification | Effects on MDSCs | Ref |
|---|---|---|---|
| Entinostat | Class I | PMN-MDSC function inhibited | (33) |
| M-MDSC migration inhibited | (34) | ||
| Valproic acid | Class I | PMN-MDSC function inhibited | (35) |
| M-MDSC migration inhibited | (36) | ||
| Mocetinostat | Class I/IV | total number of MDSCs decreased | (37) |
| Vorinostat | Class I/II | MDSC apoptosis (at higher vorinostat concentrations) | (38) |
| total number of MDSCs amplified (at lower vorinostat concentrations) | (39) | ||
| CG-745 | Class I/IIb | total number of MDSCs decreased | (40) |
| ACY241 | specific inhibitor of HDAC6 | total number of MDSCs decreased | (41) |
| Trichostatin A | Broad spectrum (except HDAC8) |
total number of MDSCs amplified (0.1-10 nM TSA) | (39) |
| PMN-MDSC number decreased | (42) |