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. 2021 Jun 2;11:647559. doi: 10.3389/fonc.2021.647559

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Copyright © 2021 Jiang, Huang, Jiang, Hou, Tian, Li, Sun, Zhang, Zhang, Li, Li, Tong and Ma

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Lactate modulated cell proliferation. (A) Representative cell images stained with nuclear DAPI and EdU (RFP) in EdU-incorporating assay. (B) Locally amplified image to clearly show EdU-positive cells, which were going through S phase of cell cycle. (C) The percentage of EdU-positive cells in the indicated groups. (D, E) Cell division progression of A549 cells observed via holographic tomographic microscopy 3D cell explorer for 6 hours, when the cells treated without (D) or with (E) lactate. (F–H) RTCA assays of cell migration and proliferation. Migration and proliferation of BEAS-2B (F), A549 (G) and H1299 (H) when the cells were treated with the indicate concentrations of lactate. (**p<0.01, ***p<0.001, ****p<0.0001).