Figure 4.

Cabozantinib-focused drug combinations in synthetic RET-mutant cell lines. (A) Western blots of null plasmid and RET C634F transformed endotypically similar cell models, confirming successful transformation and expression of RET C634F. The western blot image in this panel was generated from the grouping of two individual western blot images. No other modifications were made to the western blot image. (B) Representative 3D response manifold of RET C634F transformed RH30 cell model treated with combinations of cabozantinib and entinostat. (C) Representative 3D response manifold of null transformed RH30 cell model treated with combinations of cabozantinib and entinostat. (D) Representative Chou–Talalay Combination Index values from RET C634F cabozantinib plus entinostat combination. (E) Representative Chou–Talalay Combination Index values from null plasmid cabozantinib plus entinostat combination.