Table 2.
Comparisons of INC-regulated candidate proteins with selected published data sets.
| Regulated proteins POD 1 after incision | Gene name | Overlap | |||
|---|---|---|---|---|---|
| Neuropathic Pain (POD 28) (Barry et al. 2018) | mRNA expressed in sorted nociceptors (Jager et al. 2020) | Top 300 mRNA (Usoskin et al. 2014) | mRNA expressed in SCG (Jager et al. 2020) | ||
| Myosin-1 | Myh 1 | ||||
| Complement C3 | C3 | X | |||
| Glycogen phosphorylase, muscle form | Pygm | X | |||
| Creatine kinase M-type | Ckm | X | |||
| Fibrinogen beta chain | Fgb | X | |||
| Tropomyosin alpha-1 chain | Tpm1 | X | X | X | |
| Phosphoglucomutase-1 | Pgm1 | X | X | X | |
| Fibrinogen alpha chain | Fga | X | |||
| Fibronectin | Fn1 | X | |||
| Beta-enolase | Eno3 | X | X | ||
| Annexin A1 | Anxa1 | X | X | X | |
| Complement factor H | Cfh | X | X | ||
| Tropomyosin beta chain | Tpm2 | X | X | ||
| Adenylate kinase isoenzyme 1 | Ak1 | X | X | X | X |
| Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | Atp2a1 | ||||
| Fatty acid–binding protein, adipocyte | Fabp4 | ||||
| Thymosin beta-4 | Tmsb4x | X | X | ||
| Myosin light chain 1/3, skeletal muscle isoform | Myl1 | ||||
| Myoglobin | Mb | X | |||
| Parvalbumin alpha | Pvalb | X | X | ||
| Phosphoglycerate mutase 2 | Pgam2 | ||||
| L-lactate dehydrogenase A chain | Ldha | X | X | ||
| Carbonic anhydrase 3 | Ca3 | X | |||
| Myosin regulatory light chain 2, skeletal muscle isoform | Mylpf | X | |||
| Fructose–bisphosphate aldolase A | Aldoa | X | X | ||
| Fibrinogen gamma chain | Fgg | X | X | ||
| Pregnancy zone protein | Pzp | X | |||
| Myosin-4 | Myh4 | ||||
| Leukocyte elastase inhibitor A | Serpinb1a | X | |||
| H-2 class I histocompatibility antigen, D-B alpha chain | H2-D1 | X | X | X | |
| Phosphoglycerate kinase 1 | Pgk1 | X | X | X | X |
| Four and a half LIM domains protein 1 | Fhl1 | X | X | X | |
| Plectin | Plec | X | X | X | |
| ATP-dependent 6-phosphofructokinase, muscle type | Pfkm | X | X | X | |
| Ceruloplasmin | Cp | X | X | ||
| Asporin | Aspn | X | |||
| Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit | Dad1 | X | X | X | |
| Serotransferrin | Tf | X | |||
| Protein S100-A9 | S100a9 | X | |||
| Tropomyosin alpha-3 chain | Tpm3 | X | X | X | |
| Collagen alpha-1(XII) chain | Col12a1 | X | X | ||
| Calumenin | Calu | X | X | X | |
| Murinoglobulin-1 | Mug1 | X | |||
| Src substrate cortactin | cttn | X | X | X | |
Comparison of INC-regulated proteins with other selected datasets. Data sets are given on top of each column with respective reference. Proteins, which have been shown to be regulated during neuropathic pain at POD 28 after spared-nerve injury5 and are predicted to be involved in the ERK signaling network (Fig. 5), are highlighted by an X in bold font. Candidates, which are expressed (on the transcript level) in SCG (right column) and have been shown to be regulated at POD 3 after full sciatic nerve ligation36 are highlighted by an X in bold font in the right column. SCG, satellite glia cells.