Figure 3.

Combination therapy increases NK cell and CD8⁺ T cell frequency in the tumor microenvironment

(A) Frequency of NK cells and CD8⁺ T cells in the spleen and within the tumor of B16-E-cadherin tumor-bearing mice on day 22 post-tumor cell implantation (n = 8–13). (B) Frequency of CD69⁺ NK and CD69⁺ CD8⁺ T cells in the tumor of B16-E-cadherin tumor-bearing mice on day 22 post-tumor cell implantation (n = 8–13). (C) Frequency of indicated NK cell maturation markers on tumor infiltrating NK cells day 22 post-tumor cell implantation (n = 8–13). (Data are pooled from two experiments (A-C), error bars indicate S.E.M.) *p < .05, **p < .01, ***p < .001, and ****p < .0001.