Table 1.

Advantages and disadvantages of topical antibacterial therapy

Advantages

Disadvantages

Targeted delivery of a high concentration of drug to the site of infection Small amounts of drugs used Less potential for systemic side effects and toxicity Need for systemic antimicrobials may be avoided No interference with intestinal microbial flora Ease of administration particularly for children Low cost

Many agents associated with contact dermatitis Minimal depth of penetration, used for superficial infection only Concerns about impairment of wound healing Widespread and unrestricted use is likely to produce bacterial resistance Possibility of recurrent use and contamination after storage in patients’ home Potential for systemic absorption and toxicity if applied over a large area May be difficult for some patients to apply to larger surface areas or skin folds