Table 1.

Comparison between the clinico-histological features of classic Sweet syndrome, neutrophilic dermatosis of hands and the present case

	Classic Sweet syndrome[5]	Neutrophilic Dermatosis of Hands[6]	Our Case
Clinical features	Non-pruritic, tender, erythematous papules and plaques with pseudo-vesiculation (mammillated surface). Atypical presentation: biopsy, taken from a well-developed lesion, showed predominantly, pyoderma gangrenosum-like, erysipelas-like. Face, neck, and upper extremities usually involved. Accompanied by constitutional symptoms.	Morphologically identical to classic Sweet syndrome Mostly restricted to the dorsal hands. Rarely involve palms and dorsa of feet. Constitutional symptoms can be seen.	Multiple tender, erythematous to violaceous plaques with pseudo-vesicular appearance involving both palms and dorsa of feet. Accompanied by constitutional symptoms.
Histopathological features	Epidermis- usually normal. Spongiosis and subcorneal pustules may be seen. Papillary dermal edema with diffuse and perivascular infiltrate, predominantly neutrophilic, with occasional features of leukocytoclastic vasculitis. Infiltration may occasionally involve the subcutaneous tissue. Atypical variants: histiocytoid, lymphocytic, and eosinophilic.	Basic histopathology is similar to classic Sweet syndrome. Only one case of lymphocytic variant reported previously.[7]	Epidermis- not involved Papillary dermal edema, upper and mid-dermal perivascular infiltrate predominantly lymphocytic, with extravasation of erythrocytes. No vasculitis or subcutaneous tissue involvement.
Associated conditions	Infections Malignancy: hematological and solid organ Inflammatory bowel disease Drugs Pregnancy Autoimmune disorders: autoimmune connective tissue disorders, sarcoidosis, Behcet’s disease	Haematological disorders Infection Solid organ tumour Inflammatory bowel disease	Nothing found