. 2021 Jun 4;21(8):1–188.

Table 23:

Venous Clinical Severity Score After Cyanoacrylate Adhesive Closure vs. Radiofrequency Ablation

Author, Year (Study Design)	Baseline VCSS, MN (SD)^a		Follow-Up Time Point	Follow-Up VCSS, MN (SD)^a		P Value
Author, Year (Study Design)	CAC	RFA	Follow-Up Time Point	CAC	RFA	P Value
VeClose trial^70,72,81 (RCT, noninferiority trial)	5.5 (2.6)	5.6 (2.6)	3 d⁷⁰	4.9 (1.3)	5.0 (1.9)	.60^b
			1 mo⁷⁰	2.3 (1.7)	2.6 (2.0)
			3 mo⁷⁰	1.9 (1.6)	2.0 (2.0)
			6 mo^{72, c}	1.5^b,c (1.8^b,c)	1.6^b,c (1.9^b,c)	.5694
			12 mo^{72, c}	1.4 (1.8^b,c)	1.5 (1.9^b,c)	.5694
			24 mo^{72, c}	1.3^b,c (1.8^b,c)	1.6^b,c (2.0^b,c)	NR
			36 mo^{72, c}	1.2^b,c (1.7^b,c)	1.7^b,c (2.4^b,c)	NS (NR)
			60 mo⁸¹	1.3 (SE 0.2)	1.4 (SE 0.3)	0.6927
Ovali and Sevin, 2019⁶⁶ (Prospective comparative cohort)	5.75 (1.23)	5.79 (1.19)	12 mo	1.03 (0.96)	1.11 (0.94)	.921
Bademci et al, 2019⁶⁴ (Prospective comparative cohort)	MD 7 (r: 4–14)	MD 8 (r: 5–14)	1 mo	MD 3 (r: 2–6)	MD 3 (r: 2–6)	.06
			6 mo	MD 2 (r: 1–5)	MD 2 (r: 1–5)	.19
			12 mo	MD 1 (r: 1–4)	MD 1 (r: 1–4)	.72

Abbreviations: CAC, cyanoacrylate adhesive closure; d, day; MD, median; mo, month(s); MN, mean; NR, not reported; NS, not significant; r, range (min–max); RCT, randomized controlled trial; RFA, radiofrequency ablation; SD, standard deviation; SE, standard error; VCSS, Venous Clinical Severity Score.

Unless otherwise stated.

P value is for repeated measures ANOVA (baseline, 3 d, 1 mo, 3 mo).⁷⁰

Values approximated and/or calculated from data presented in figures in Morrison et al, 2019⁷² using WebPlotDigitizer software.⁴³