. 2021 Jun 4;21(8):1–188.

Table 25:

Quality of Life Score After Cyanoacrylate Adhesive Closure vs. Radiofrequency Ablation

Author, Year (Study Design)	Baseline Score, MN (SD)^a		Follow-Up Time Point	Follow-Up Score, MN (SD)^a		P Value
Author, Year (Study Design)	CAC	RFA	Follow-Up Time Point	CAC	RFA	P Value
Disease-Specific Quality of Life: Aberdeen Varicose Vein Questionnaire
VeClose trial^70–72,81 (RCT, noninferiority trial)	18.9 (9.0)	19.4 (9.9)	1 mo⁷⁰	11.9 (7.1)	12.6 (8.3)	0.53^b
			3 mo⁷⁰	11.6 (7.5)	10.7 (8.6)	0.53^b
			6 mo⁷²	10.2^c(5.6^c)	9.1^c (7.1^c)	NS (NR)
			12 mo⁷²	9.7^c (7.1^c)	8.4^c (6.5^c)	NS (NR)
			24 mo⁷²	8.2^c (7.9^c)	8.3^c (7.5^c)	NS (NR)
			36 mo⁷²	7.3^c (6.4^c)	8.2^c (7.8^c)	NS (NR)
			60 mo⁸¹	8.3 (9.6^d)	6.6 (5.7^d)	.3418
Ovali and Sevin, 2019⁶⁶ (prospective comparative cohort)	17.43 (6.38)	18.21 (6.93)	12 mo	4.93 (1.56)	5.13 (1.49)	.752
Bademci et al, 2019⁶⁴ (prospective comparative cohort)	MD 17 (range 15–21)	17 (11–21)	1 mo	7 (6–9)	8 (5–13)	.10
			6 mo	5 (4–7)	6 (3–10)	.84
			12 mo	4 (3–6)	4 (1–9)	.61
Generic Quality of Life: EQ-5D TTO
VeClose trial^70,81 (RCT, noninferiority trial)	0.935 (.113)	0.918 (.116)	1 mo⁷⁰	0.965 (.113)	0.961 (.106)	.34^b
			3 mo⁷⁰	.965 (.095)	.965 (.083)	.34^b
			60 mo⁸¹	0.97 (.08)	.94 (.11)	NR

Abbreviations: CAC, cyanoacrylate adhesive closure; EQ-5D TTO, EuroQol 5-Dimension Time Trade Off; MD, median; MN, mean; mo, month(s); NR, not reported; NS, not significant; RCT, randomized controlled trial; RFA, radiofrequency ablation; SD, standard deviation.

Unless otherwise noted values are mean and standard deviation.

Repeated-measures ANOVA comparing baseline, 1 mo, and 3 mo.⁷⁰

Values approximated and/or calculated from data presented in figures in Morrison et al, 2019⁷² using WebPlotDigitizer software.⁴³

Standard deviation calculated from data presented in Figure 3 of Morrison et al, 2020⁸¹ using WebPlotDigitizer software.⁴³