Table 4:
Vein Closure After Mechanochemical Ablation vs. Thermal Endovenous Ablation
| Vein Closure, % (n/N) | |||||
|---|---|---|---|---|---|
| Author, Year (Study Design) | Follow-Up Time Point | MOCA | EVLA | RFA | P Value |
| Mohamed et al, 202083 (RCT) | 12 mo | 77 (53/69) | 91 (63/69) | — | .020 |
| Vahaaho et al, 2019,80 2020 (RCT) | 12 mo 36 mo |
82 (45/55) 80a (40/50) |
100 (33/33) 100 (31/31) |
100 (29/29) 100 (25/25) |
< .05 < .01 |
| Holewijn et al, 201979 (RCT) | 30 d 12 mo 24 mo |
91.3 (94/103) 83.5 (66/81)b 80.0 (55/76) |
— | 99.0 (102/103) 94.2 (67/72)b 88 (69/81)b |
.045 .025 .066 |
| Lane et al, 2017; Bootun et al, 201673,74 (RCT) | 1 mo 6 mo |
93c,d (64/69)b 87c (54/62)b |
— | 92c,d (55/60)b 93c (55/59)b |
.403 .483 |
| Vun et al, 201576 (prospective cohort) | 4–6 wke | 91% (50/55) | 93%f (NR) | 93%f (NR) | NR |
Abbreviations: d, day; EVLA, endovenous laser ablation; mo, month; MOCA, mechanochemical ablation; n, number of people; N, total number of people in group; NR, not reported; RFA, radiofrequency ablation; wk, week.
Excludes 1 person who had MOCA and then developed recanalization that was re-treated with EVLA and had complete occlusion.
Calculated from data presented in publication.
Includes both complete occlusion and partial occlusion (defined as > 5 cm proximally occluded, > 5 cm open distally).74
Data presented are from Lane et al.74 1-month data presented in Table 4 in Bootun et al73 show 83% complete closure in MOCA group and 92% complete closure in RFA group; however, results reported in the text of the same article74 and in Lane et al74 differ.73
Study reports duplex ultrasound done 4–6 weeks after procedure.76
For EVLA and RFA, this study only reported proportion, citing another study for the proportion of technical success.76