TABLE VIII:
Gene enrichment analysis of the identified genes (High WRAT group). Q-values represent multiple testing corrected p-values.
| Pathway Name | Pathway Source | Set size | Contained | p-value | q-value |
|---|---|---|---|---|---|
| Regulation of neurotransmitter levels | Gene Ontology | 335 | 9 | 6.77E-10 | 1.04E-07 |
| Transmission across Chemical Synapses | Reactome | 224 | 7 | 7.75E-08 | 2.40E-06 |
| Synaptic signaling | Gene Ontology | 711 | 10 | 3.17E-08 | 2.43E-06 |
| Insulin secretion - Homo sapiens (human) | KEGG | 85 | 5 | 3.26E-07 | 5.06E-06 |
| Organelle localization by membrane tethering | Gene Ontology | 170 | 6 | 1.34E-07 | 6.84E-06 |
| Regulation of synaptic plasticity | Gene Ontology | 179 | 6 | 1.89E-07 | 7.21E-06 |
| Exocytosis | Gene Ontology | 909 | 10 | 3.06E-07 | 9.36E-06 |
| Membrane docking | Gene Ontology | 179 | 6 | 1.82E-07 | 1.28E-05 |
| Vesicle docking involved in exocytosis | Gene Ontology | 45 | 4 | 5.11E-07 | 1.30E-05 |
| Plasma membrane bounded cell projection part | Gene Ontology | 1452 | 12 | 3.05E-07 | 1.34E-05 |
| Cell projection part | Gene Ontology | 1452 | 12 | 3.05E-07 | 1.37E-05 |
| Neurotransmitter release cycle | Reactome | 51 | 4 | 1.76E-06 | 1.37E-05 |
| Synaptic Vesicle Pathway | Wikipathways | 51 | 4 | 1.76E-06 | 1.37E-05 |
| Neuronal System | Reactome | 368 | 7 | 2.25E-06 | 1.39E-05 |
| Secretion by cell | Gene Ontology | 1493 | 12 | 4.13E-07 | 1.45E-05 |
| Adrenergic signaling in cardiomyocytes - Homo sapiens (human) | KEGG | 144 | 5 | 4.47E-06 | 2.31E-05 |
| Gastric acid secretion - Homo sapiens (human) | KEGG | 75 | 4 | 8.34E-06 | 3.70E-05 |
| Neuron part | Gene Ontology | 1713 | 12 | 1.83E-06 | 4.09E-05 |
| Plasma membrane bounded cell projection | Gene Ontology | 2098 | 13 | 2.22E-06 | 4.87E-05 |