Fig 8.

Manhattan plot of results from a multi-encoding GWAS for T2D (A) and AMD (B). GWAS were performed using the additive (red circle), dominant (yellow square), recessive (green diamond) and codominant (blue triangle) encodings for A) 358,569 SNPs and 20,341samples (7,101 cases and 13,240 controls, 53% female) for type 2 diabetes and B) 311,161 SNPs and 13,153 samples (961 cases and 4,129, 56% female) for AMD. SNPs with EDGE-derived alpha values between 0 and 1 were sorted by the alpha value along the x-axis. Along the y-axis is the–log10 of the uncorrected p-value. The black line denotes the genome-wide significance threshold (5×10⁻⁸).